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RESEARCH STUDIES

Over a decade of investment in science

Since 2010, we've set out to formulate a comprehensive and effective Foundational Nutrition supplement.

Our driving belief: High-quality ingredients delivering essential nutrients in forms the body can easily absorb.

RESEARCH TIMELINE

Setting a new standard in research

Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1. We followed a universally acknowledged hierarchy of scientific rigor, looking beyond ingredient data to test our complete formula and validate the synergy of how ingredients work together.

01 — CLINICAL TRIAL RESULTS
Clinical Trial
A double-blind, randomized, placebo-controlled trial. We monitored 30 healthy adults ages 21-49 over the course of 1 month, measuring the digestive impact of AG1 through stool samples. Research was conducted with a third party to mitigate bias.

AG1 was shown to enrich the gut microbiome, more than doubling the levels of friendly bacteria typically found in a healthy gut.↟

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increase in gut-friendly bacteria vs. control↟

WHY THIS MATTERS
These good bacteria live in the gut as part of a healthy microbiome that’s involved in the digestion of nutrients.

↟ Data on file, 2023. In a double-blind, randomized, placebo-controlled clinical trial assessing 30 healthy adults ages 21-49 over the course of 1 month.

02 — THE IN-VITRO STUDY RESULTS
In-vitro SHIME study
(Simulator of the Human Intestinal Microbial Ecosystem) A simulation of the human gastrointestinal tract, used to study the effects of AG1 on the gut in a controlled, highly reliable laboratory environment.

In a set of in-vitro studies simulating the human gastrointestinal tract, AG1 was shown to have measurable effects on the gut microbiome.*‡

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more minerals available for absorption vs. a multivitamin tablet*

WHY THIS MATTERS
Adequate nutrient levels are needed to deliver their intended benefits. The more accessible a nutrient is to the digestive tract, the easier it is for absorption.

* In an in-vitro study that compared AG1 powder to a multivitamin tablet using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to deliver better absorbable nutrients than the multivitamin tablet.

Sapp, P. et al. Appl Biosci. 2023.

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increase in short-chain fatty acid production vs. control‡

WHY THIS MATTERS
SCFAs are indicators of a thriving microbiome. And the production of SCFAs show that the gut-friendly bacteria and fibre in AG1 get to the colon where they have the most impact.

‡ In an in-vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design.

Kirby, T. et al. Nutraceuticals. 2023.

03 — OBSERVATIONAL STUDY RESULTS
Observational study
A study conducted with 35 healthy adults ages 25-48. We measured how participants reported feeling and behaving in different increments over the course of 3 months, and validated the data with a third-party clinical research organization to mitigate bias.

In a single-arm study that assessed the self-perceived efficacy of AG1, participants reported feeling positive impacts on energy, mental performance, and skin.†

AT 1 MONTH

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AT 3 MONTHS

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saw clear skin†
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noticed less cravings during the day†
WHY THIS MATTERS
Internal changes aren't always felt. By giving your body the routine nutrients it needs, you’re able to experience benefits that build each day.†

† Data on file, 2023. The above results may be attributed to the following ingredients and health effects: Vitamins B6, B12 and phosphorus contribute to normal energy-yielding metabolism. Zinc contributes to normal carbohydrate metabolism. Pantothenic acid contributes to normal mental performance. Thiamine, niacin, vitamin B6, vitamin B12, biotin, folate, and vitamin C contribute to normal psychological function. Vitamin A and biotin contribute to the maintenance of normal skin. Chromium contributes to the maintenance of normal blood glucose levels. Participants felt that they prefer to eat healthy and avoid unhealthy habits when they implemented AG1 into their daily routine.

"We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients, together with good bacteria — all in a powder form that delivers more ready-to-digest nutrients than a tablet."

Dr. Ralph Esposito ND, LAc — Chief Science & Nutrition Officer at AG1

Our Team & Findings

Our research team

To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.

Peer-reviewed research

In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.

NUTRIENTS

Foundational Nutrition: Implications for Human Health

Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.

Read paper
FRONTIERS

Nutrient synergy: definition, evidence, and future directions

Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.

Read paper
NUTRACEUTICALS

The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®

Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, and mushrooms.

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APPLIED BIOSCIENCE

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. which contains vitamins, minerals, phytonutrients, wholefood concentrates, and mushrooms.

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CURRENT ISSUES IN MOLECULAR BIOLOGY

AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model

Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.

Read paper

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FAQs

What is a SHIME model?

The SHIME model, which stands for Simulator of the Human Intestinal Microbial Ecosystem, is an in vitro model used in research to study the human gastrointestinal tract. It consists of a series of interconnected sections, called bioreactors, that mimic the physiological and biological conditions found in the human gut, including the stomach, small intestine, and colon.

Why did you start with a SHIME study?

What is a single-arm study?

How do you validate your research data on AG1?

What measures do you take to ensure the quality of AG1?

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* Caution: Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the indicated daily intake. Keep out of reach of children. Please inform and consult your doctor before consuming this product. Not suitable for children and adolescents under 18 years, pregnant or breastfeeding women. Refrain from taking other food supplements containing zinc. Persons taking anticoagulant medication should seek medical advice before consuming vitamin K-containing supplements.

* Genuine reviews from customers who received a review link after purchase.

** Offer valid for new subscribers only.

Immune System

1: Copper, folate, selenium, zinc, and vitamins A, B12, B6, and C contribute to the normal function of the immune system.

Metabolism

2: Vitamins C, B6 and B12, as well as thiamine, riboflavin, niacin, biotin, pantothenic acid, calcium, phosphorus, copper, and manganese contribute to normal energy-yielding metabolism. Biotin, zinc, and chromium contribute to normal macronutrient metabolism. Vitamin A and riboflavin contribute to normal metabolism of iron. Zinc contributes to normal acid-base metabolism.

Healthy Cells

3: Vitamins E and C, as well as riboflavin, zinc, copper, manganese and selenium, contribute to the protection of cells from oxidative stress. Zinc contributes to normal DNA synthesis. Phosphorus contributes to normal function of cell membranes.

Mental Performance; Mental Focus; Nervous System

4: Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid and folic acid contribute to the reduction of tiredness and fatigue. Pantothenic acid contributes to normal mental performance. Zinc contributes to normal cognitive function. Vitamins C, B6, B12, thiamine, riboflavin, niacin, biotin, and copper contribute to normal functioning of the nervous system.

Healthy bones

5: Calcium contributes to the maintenance of normal bones. Protein, phosphorus, zinc, and manganese contribute to the maintenance of normal bones. Vitamin C contributes to normal collagen formation for the normal function of bones.

Cardiovascular System

6: Thiamine contributes to the normal function of the heart. Vitamins B6 and B12 contribute to normal red blood cell formation. Vitamin C contributes to normal collagen formation for the normal function of blood vessels.

Skin, hair, nails

7: Vitamin A, riboflavin, niacin, biotin and zinc contribute to the maintenance of normal skin. Vitamin C contributes to normal collagen formation for the normal function of skin. Biotin, zinc and selenium contribute to the maintenance of normal hair. Copper contributes to normal skin and hair pigmentation and to normal connective tissue. Selenium and zinc contribute to the maintenance of normal nails.

Hormonal Health

8: Vitamin B6 contributes to the regulation of hormonal activity. Pantothenic acid contributes to normal synthesis and metabolism of steroid hormones, vitamin D, and some neurotransmitters. Zinc contributes to the maintenance of normal testosterone levels in the blood. Selenium contributes to normal thyroid function and normal spermatogenesis. Zinc contributes to normal fertility and normal reproduction. Chromium contributes to the maintenance of normal blood glucose levels.

Digestion

9: Calcium contributes to the normal function of digestive enzymes. Biotin contributes to the maintenance of normal mucous membranes (e.g., intestinal mucosa).

Muscles

10: Calcium contributes to normal muscle function. Proteins contribute to the maintenance of muscle mass and an increase in muscle mass.

Healthy eyes

11: Vitamin A, riboflavin and zinc contribute to the maintenance of normal vision.

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