RESEARCH STUDIES

Over a decade of investment in science

Since 2010, we've set out to formulate a comprehensive and effective Foundational Nutrition supplement.

Our driving belief: High-quality ingredients delivering essential nutrients in forms the body can easily absorb.

RESEARCH TIMELINE

Setting a new standard in research

Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1. We followed a universally acknowledged hierarchy of scientific rigor, looking beyond ingredient data to test our complete formula and validate the synergy of how ingredients work together.

01 — CLINICAL TRIAL RESULTS

AG1 was shown to enrich the gut microbiome, more than doubling the levels of friendly bacteria typically found in a healthy gut.↟

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increase in gut-friendly bacteria vs. control↟

WHY THIS MATTERS

These good bacteria live in the gut as part of a healthy microbiome that’s involved in the digestion of nutrients.

↟ Data on file, 2023. In a double-blind, randomized, placebo-controlled clinical trial assessing 30 healthy adults ages 21-49 over the course of 1 month.

02 — THE IN-VITRO STUDY RESULTS

In a set of in-vitro studies simulating the human gastrointestinal tract, AG1 was shown to have measurable effects on the gut microbiome.*‡

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more minerals available for absorption vs. a multivitamin tablet*

WHY THIS MATTERS

Adequate nutrient levels are needed to deliver their intended benefits. The more accessible a nutrient is to the digestive tract, the easier it is for absorption.

* In an in-vitro study that compared AG1 powder to a multivitamin tablet using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to deliver better absorbable nutrients than the multivitamin tablet.

Sapp, P. et al. Appl Biosci. 2023.

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increase in short-chain fatty acid production vs. control‡

WHY THIS MATTERS

SCFAs are indicators of a thriving microbiome. And the production of SCFAs show that the gut-friendly bacteria and fibre in AG1 get to the colon where they have the most impact.

‡ In an in-vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design.

Kirby, T. et al. Nutraceuticals. 2023.

03 — OBSERVATIONAL STUDY RESULTS

In a single-arm study that assessed the self-perceived efficacy of AG1, participants reported feeling positive impacts on energy, mental performance, and skin.†

AT 1 MONTH

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of participants felt sustained energy†
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of participants felt AG1 was easy to incorporate into their routine

AT 3 MONTHS

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saw clear skin†
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noticed less cravings during the day†

WHY THIS MATTERS

Internal changes aren't always felt. By giving your body the routine nutrients it needs, you’re able to experience benefits that build each day.†

† Data on file, 2023. The above results may be attributed to the following ingredients and health effects: Vitamins B6, B12 and phosphorus contribute to normal energy-yielding metabolism. Zinc contributes to normal carbohydrate metabolism. Pantothenic acid contributes to normal mental performance. Thiamine, niacin, vitamin B6, vitamin B12, biotin, folate, and vitamin C contribute to normal psychological function. Vitamin A and biotin contribute to the maintenance of normal skin. Chromium contributes to the maintenance of normal blood glucose levels. Participants felt that they prefer to eat healthy and avoid unhealthy habits when they implemented AG1 into their daily routine.

"We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients, together with good bacteria — all in a powder form that delivers more ready-to-digest nutrients than a tablet."

Dr. Ralph Esposito ND, LAc — Chief Science & Nutrition Officer at AG1

Our research team

To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.

Dr. Ralph Esposito

ND, Lac — Functional Medicine

Dr. Esposito is a licensed naturopathic physician focused on optimizing healthspan and lifespan through preventive and lifestyle practices. He completed his training as a medical intern in Urology at NYU Langone, holds a clinical Masters in Acupuncture and Chinese Medicine, and is a certified Functional Medicine doctor (IFMCP). Dr. Esposito employs evidence-based tactics to provide a personalized approach to preventative medicine. He is active in the health and education sectors, and is an Adjunct Professor in the Nutrition and Dietetics Program at New York University alongside his role as Chief Science & Nutrition Officer at AG1.

Dr. Lara Nyman

PhD — Molecular Endocrinology

Dr. Nyman is a Research & Development leader with a passion for science-led innovation in health and wellness. She has more than two decades of experience in research and discovery across academic, start-up, and Fortune 500 companies. Most recently Dr. Nyman led research in a healthtech/biotech start up that aimed to revolutionize the way we drink water. Prior to that, she led discovery, innovation, and growth for global Pepsico brands, including Gatorade. Lara is passionate about metabolic health and holds a PhD in Cellular and Molecular Physiology. She completed her post-doctoral training in Molecular Endocrinology at Vanderbilt Diabetes Research Center. Dr. Nyman has authored and co-authored 25 peer-reviewed publications, two patents, and has received multiple awards for her work. She currently serves as VP of Research & Discovery at AG1.

Dr. Ren-hai Lau

PhD, TCMD — Traditional Chinese Medicine

Dr. Lai holds a Traditional Chinese Medicine Doctor degree and a PhD from Beijing University of Chinese Medicine and the University of Illinois Urbana-Champaign, respectively. His research and training focused on plant bioactive components and the gut microbiome, which has resulted in numerous peer-reviewed papers and a patent. After completing his doctoral training, Dr. Lai started his career in the food and supplement industry, where he worked in the R&D team of Fortune 500 companies, such as General Mills and Mead Johnson Nutrition. He has specialized in new product development and product lifecycle management and has played a key role in introducing innovative products to the market. As a scientist, Dr. Lai is committed to designing products that are safe and effective. He currently holds the position of Director of Innovation and Product Development at AG1.

Dr. Tess Marshall

ND — Integrative Health

Dr. Marshall is a licensed naturopathic physician focused on integrative health and wellness, with a specialty in regenerative medicine and women’s health. After receiving her doctoral degree from Bastyr University, she practiced as a clinician at a platelet-rich plasma (PRP), peptide, and nutritional IV clinic in San Diego, CA, and led product innovation at Nutrafol. Dr. Marshall has published various research on nutrition and dermatology in peer-reviewed journals, and is passionate about expanding access to health education and contributing to the evolving field of research in nutritional science. She is currently the Director of Product Marketing and Education at AG1.

Dr. Sonia Malani

ND — Integrative Medicine

Dr. Malani is a licensed naturopathic physician and board-certified integrative oncologist, author, and researcher. She earned her naturopathic medicine doctorate from Bastyr University, following a B.A. in psychology from New York University. Dr. Malani has over a decade of experience supporting patients with cancer and chronic illnesses. She is a contributing author to Ann Berger’s 5th Edition of Principles and Practice of Palliative Care and Supportive Oncology and has conducted multiple clinical trials exploring the effectiveness of integrative medicine with a focus on epigenetics, oncology, nutrition, and psychoneuroimmunology. She is currently the Senior Manager of Scientific Communication and Education at AG1.

Dr. Jeremy Townsend

PhD — Exercise Physiology

Dr. Townsend earned his doctoral degree in Exercise Physiology from the University of Central Florida and has published over 80 peer-reviewed research articles focusing on sport nutrition, exercise performance, skeletal muscle physiology, and dietary supplementation. He has given numerous presentations and talks on nutrition and dietary supplementation at international conferences. Dr. Townsend is a Certified Sport Nutritionist (CISSN) through the International Society of Sport Nutrition (ISSN) and a Certified Strength and Conditioning Specialist with Distinction (CSCS*D) through the National Strength and Conditioning Association (NSCA). Dr. Townsend is currently the Research Manager at AG1 and an Adjunct Professor at Concordia University Chicago.

Dr. Trevor Kirby

PhD — Immunology and Microbiology

Pharmaceutical Sciences and Molecular Medicine from Washington State University and a masters degree in Biology with an emphasis in Immunology and Microbiology from Eastern Washington University. His area of expertise centers on the connection between the human gut microbiome and the nervous system. He has published various research in the fields of immunology, microbiology, pharmacology, genetics, and biochemistry, and has given sponsored and educational talks on novel therapeutic microbiome approaches. Passionate about science and science education, Dr. Kirby regularly engages with the greater community through podcasts and volunteering with local high school student STEM groups. He is currently a Research Scientist at AG1.

Dr. Philip Sapp

PhD — Nutritional Science

Dr. Sapp holds a doctoral degree in Nutritional Sciences from Penn State University and a masters degree in Exercise and Nutritional Sciences from Lipscomb University. He specializes in the effect of diet on cardiometabolic risk factors and the gut microbiome in adults at risk for chronic disease. As a clinical researcher, Dr. Sapp has designed, conducted, and presented on several clinical trials and has published numerous peer-reviewed papers and book chapters. Dr. Sapp is passionate about nutrition research and is currently a Research Scientist at AG1.

Dr. Caitlyn Edwards

PhD, RD — Nutritional Science

Dr. Edwards completed her doctoral degree in Nutritional Sciences at the University of Illinois at Urbana Champaign, and completed post-doctoral training at The Pennsylvania State University. She has experience in a variety of academic, industry, and non-profit settings, with over 50 published peer-reviewed articles in the fields of nutrition, neuroscience, technology, and eating behavior. Her research centers around the impact of dietary intake and eating behaviors on health across the lifespan. Alongside being a Nutrition Scientist, she is a Registered Dietitian with her certification of training in obesity in pediatrics and adults. Dr. Edwards is passionate about health and nutrition equity and helping others live happier and healthier lives. She is currently a Senior Research Scientist at AG1.

Peer-reviewed research

In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.

NUTRIENTS

Foundational Nutrition: Implications for Human Health

Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.

Read paper
FRONTIERS

Nutrient synergy: definition, evidence, and future directions

Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.

Read paper
NUTRACEUTICALS

The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®

Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, and mushrooms.

Read paper
APPLIED BIOSCIENCE

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. which contains vitamins, minerals, phytonutrients, wholefood concentrates, and mushrooms.

Read paper
CURRENT ISSUES IN MOLECULAR BIOLOGY

AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model

Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.

Read paper

One scoop. Every morning. For life.

FAQs

The SHIME model, which stands for Simulator of the Human Intestinal Microbial Ecosystem, is an in vitro model used in research to study the human gastrointestinal tract. It consists of a series of interconnected sections, called bioreactors, that mimic the physiological and biological conditions found in the human gut, including the stomach, small intestine, and colon.

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Do not exceed the indicated daily intake. Keep out of reach of children. Please inform and consult your doctor before consuming this product. Not suitable for children and adolescents under 18 years, pregnant or breastfeeding women. Persons taking anticoagulant medication should seek medical advice before consuming vitamin K-containing supplements.

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** Based on formula prior to upgrades. For more information on our upgraded formula available in your region, click HERE.

Digestion

1. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Calcium contributes to the normal function of digestive enzymes.
Biotin contributes to the maintenance of normal mucous membranes (e.g., intestinal mucosa).

Immune System

2. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Copper, folate, selenium, zinc, and vitamins A, B12, B6, and C contribute to the normal function of the immune system.

Mental Performance; Cognitive Function; Nervous System; Psychological Function

3. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid and folic acid contribute to the reduction of tiredness and fatigue.
Pantothenic acid contributes to normal mental performance.
Zinc contributes to normal cognitive function.
Vitamins C, B6, B12, thiamine, riboflavin, niacin, biotin, copper and potassium contribute to normal functioning of the nervous system.
Thiamine, niacin, vitamin B6, vitamin B12, biotin, folate, and vitamin C contribute to normal psychological function.

Metabolism

4. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Vitamins C, B6 and B12, as well as thiamine, riboflavin, niacin, biotin, pantothenic acid, calcium, phosphorus, copper, and manganese contribute to normal energy-yielding metabolism.
Biotin, zinc, and chromium contribute to normal macronutrient metabolism.
Vitamin A and riboflavin contribute to normal metabolism of iron.
Zinc contributes to normal acid-base metabolism.
Molybdenum contributes to normal sulphur amino acid metabolism.

Healthy Cells

5. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Vitamins E and C, as well as riboflavin, zinc, copper, manganese and selenium, contribute to the protection of cells from oxidative stress.
Phosphorus contributes to normal function of cell membranes.

Hormonal Health

6. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Vitamin B6 contributes to the regulation of hormonal activity.
Pantothenic acid contributes to normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters.
Zinc contributes to the maintenance of normal testosterone levels in the blood.
Selenium contributes to the normal utilisation of iodine in the production of thyroid hormones.
Zinc contributes to normal fertility and reproduction.
Selenium contributes to normal spermatogenesis.

Heart Health

7. As part of a healthy diet containing a variety of foods, AG1 is a source of:
Thiamine contributes to the normal function of the heart.
Vitamin C contributes to normal blood vessels structure and function.
Vitamin B6 contributes to normal red blood cell formation.
Vitamin B2 contributes to the maintenance of normal red blood cells.

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