Can Riboflavin Help with Migraines?

Riboflavin, also known as Vitamin B2, may support energy metabolism and could play a role in migraine treatment. Find out how.

3 MIN READ — 03/18/2025

Riboflavin, also known as Vitamin B2, is a true multitasker for our health. Not only does it support energy metabolism, but it may also help in managing migraines. Here’s everything you need to know about this essential vitamin.

What Is Riboflavin (Vitamin B2)?

Wondering what riboflavin is? In short, this essential vitamin plays a key role in our energy metabolism. It’s crucial for various processes that require specific enzymes—many of which are made up of riboflavin.

The conversion of carbohydrates, proteins, and fats into energy happens smoothly in our bodies only when enough Vitamin B2 is present. Since Vitamin B2 is an essential amino acid, our bodies cannot produce it on their own. This means we need to obtain it through our diet. If you’re looking to boost your energy levels and improve your fitness, it might be time to take a closer look at your eating habits.

What Does Vitamin B2 Do for Your Body?

The importance of riboflavin (Vitamin B2) cannot be overstated. It’s essential for cell function, growth, and development, and it helps detoxify foreign substances such as medications. Since it’s a water-soluble vitamin, your body needs a regular intake to avoid gaps in supply.

It’s worth checking the reference values for your daily intake. How much riboflavin you need depends on your energy requirements, age, and gender. According to the German Nutrition Society (DGE), teenage boys have a particularly high requirement at 1.6 mg per day. Teenage girls need between 0.9 and 1.2 mg daily. Pregnant women also require more, at around 1.3 to 1.4 mg per day. For adults who aren’t pregnant or breastfeeding, women need between 1.0 and 1.1 mg daily, while men in this age group need between 1.3 and 1.4 mg.

Riboflavin in Foods: The Best Vitamin B2 Sources

To meet your riboflavin needs, take a closer look at your diet. Many foods contain Vitamin B2, but the content can vary. Here’s a table listing the top foods rich in riboflavin:

Top foods rich in riboflavin
Top foods rich in riboflavin

Recognising Riboflavin Deficiency: Symptoms and Causes

Various symptoms can indicate a riboflavin deficiency. Skin and mucous membrane issues are common signs—such as cracked corners of the mouth or an inflamed oral mucosa. You may also experience flaky eczema. Eye symptoms can also occur, including lens clouding, corneal changes, or conjunctivitis. Riboflavin deficiencies often accompany other nutrient deficiencies, and excessive alcohol consumption or certain medications can also play a role. Ensuring a healthy, balanced diet is key to avoiding such deficiencies.

Good news: you don’t need to worry about riboflavin overdose. To date, no adverse health effects have been associated with excessive intake of Vitamin B2. This makes it easier to consider supplements as part of your regular diet if needed.

Riboflavin for Migraines: Can Vitamin B2 Help?

One of the many benefits of Vitamin B2 is its potential in migraine treatment. Researchers suggest there may be a connection between riboflavin, mitochondria, and migraine development. Mitochondria are vital in our bodies as energy producers, and riboflavin may help reduce stress or nerve inflammation—both of which can influence migraines.

At a Glance

  • 01.

    Riboflavin (Vitamin B2) plays a central role in energy metabolism, aiding in the conversion of carbohydrates, proteins, and fats into energy. As an essential vitamin, it must be obtained through diet, as the body cannot produce it on its own.

  • 02.

    A Vitamin B2 deficiency can cause symptoms such as inflamed oral mucosa, cracked corners of the mouth, skin problems, and eye issues. Maintaining a healthy, balanced diet is crucial for ensuring an adequate riboflavin intake.

  • 03.

    Riboflavin may also aid in migraine treatment by supporting mitochondria, reducing stress, and alleviating nerve inflammation. Studies suggest Vitamin B2 could positively affect migraine symptoms.

Article Sources

Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the indicated daily intake. Keep out of reach of children. Please inform and consult your doctor before consuming this product. Not suitable for children and adolescents under 18 years, pregnant or breastfeeding women. Refrain from taking other food supplements containing zinc. Persons taking anticoagulant medication should seek medical advice before consuming vitamin K-containing supplements.

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º Food Supplement. In combination with a healthy diet and exercise.

ª Survey on the awareness of multi-nutrient powders with 211 consumers aged 18 to 49 in Germany, 09/24.

↡ Survey of 527 AG1 customers after 12+ days of use, 2024. The survey was conducted on a previous version of AG1’s continually evolving formulation. The survey results can be transferred to the current version of the formula due to no or scientifically negligible changes in supporting nutrients. Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid, and folate help reduce tiredness and fatigue. Pantothenic acid supports mental performance. Calcium supports normal digestive enzyme function, while biotin maintains normal mucous membranes, such as the gut lining.

Immune System

1: With vitamins A, C, B6 and B12 as well as folate, zinc, copper and selenium, AG1 contributes to the normal function of the immune system. Vitamin C contributes to maintain the normal function of the immune system during and after intense physical exercise.

Energy; Metabolism

2: Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid and magnesium contribute to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. With vitamins C, B6, B12, as well as thiamine, riboflavin, niacin, biotin, pantothenic acid, calcium, phosphorus, copper and manganese, AG1 contributes to normal energy-yielding metabolism. Magnesium contributes to electrolyte balance. Biotin, zinc and chromium contribute to normal macronutrient metabolism.

Cell Protection

3: With vitamins E and C as well as riboflavin, zinc, copper and selenium, AG1 contributes to the protection of cells from oxidative stress. Phosphorus contributes to normal function of cell membranes. Folate, Vitamin B6 and B12 contribute to normal homocysteine metabolism.

Mental Performance; Psychological Function; Nervous System

4: With pantothenic acid, AG1 contributes to normal mental performance. Zinc contributes to normal cognitive function. With vitamins C, B6, B12, B1, B3 and B7 AG1 contributes to normal psychological function and to normal functioning of the nervous system. Calcium contributes to normal neurotransmission.

Skin, Hair & Nails

5: With vitamins A, as well as riboflavin, niacin, biotin and zinc, AG1 contributes to the maintenance of normal skin. Vitamin C contributes to normal collagen formation for the normal function of skin. Vitamin B7, zinc and selenium contribute to the maintenance of normal hair. Zinc and selenium contribute to the maintenance of normal nails.

Hormonal System

6: With vitamin B6, AG1 contributes to the regulation of hormonal activity. Zinc contributes to the maintenance of normal testosterone levels in the blood. Selenium contributes to the normal thyroid function. With chromium, AG1 contributes to the maintenance of normal blood glucose levels.

Digestion

7: Calcium contributes to the normal function of digestive enzymes. Biotin AG1 contributes to the maintenance of normal mucous membranes (e.g. intestinal mucosa).

Muscles

8: With calcium and magnesium, AG1 contributes to normal muscle function.