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      © AG1

      Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the indicated daily intake. Keep out of reach of children. Please inform and consult your doctor before consuming this product. Not suitable for children and adolescents under 18 years, pregnant or breastfeeding women. Refrain from taking other food supplements containing zinc. Persons taking anticoagulant medication should seek medical advice before consuming vitamin K-containing supplements.

      * Genuine reviews from customers who received a review link after purchase.

      **Offer valid for new subscribers only. Savings apply to first month only. First month includes AG1 (worth £79) plus a Welcome Kit (worth £28), Vitamin D3+K2 (worth £25), 5 Travel Packs (worth £15) – total value £147, reduced to £79 (save 40%+). Subscription continues at £79/month thereafter unless cancelled.

      ↡ Ongoing survey of 3,000+ AG1 customers after 12+ days of use, 2024.

      § In a third-party, observational study conducted on 35 healthy adults ages 25-48 assessing the self-perceived efficacy of AG1 over the course of 3 months. The study was conducted on a similar version of AG1's continually evolving formulation. The study results are transferable because of comparable ingredients and amounts.

      ○ Ongoing survey of customers from 12 European countries who have been taking AG1 for an average of 9 days.

      ⬥ Comparison (2025) with individual supplements in comparable amounts that are typically sold at retail: vitamin B complex, vitamin A, vitamin C, vitamin E, bacterial cultures, zinc, magnesium, calcium, selenium, chromium, manganese, molybdenum, coenzyme Q10, greens powders (from sea algae such as spirulina, barley leaf, wheatgrass, dandelion, spinach powder, etc.), mushroom supplements (reishi, shiitake). AG1 monthly price for single subscription (£79) calculated down to 30 daily portions. The comparison prices are the average prices per daily portion of three individual products (where available) available online in September 2025 (sample selection) for each compared category, each with identical ingredients. To ensure a fair basis for comparison, where the comparison products have different dosages, the prices were mathematically adjusted to correspond to the dosage contained in AG1. The amounts for the B complex may vary slightly. For the greens powders and the mushroom complex, the prices were compared per daily dose, quantities and ingredients vary and are not 100% identical.

      Research Studies
      a. In a triple-blind, randomised, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
      b. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts in 20 active adults ages 19-37.
      c. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts of 24 healthy adults with occasional GI distress ages 26-59.
      d. In a double-blind, randomised, placebo-controlled cross-over clinical trial assessing bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.
      The studies were conducted on a similar version of AG1's continually evolving formulation. The transferability of the study results is ensured because of comparable ingredients and amounts.

      ◊ Key health benefits:

      (1) Immune system: With vitamins A, C, B6 and B12 as well as folate, zinc, copper and selenium, AG1 contributes to the normal function of the immune system. Vitamin C contributes to maintain the normal function of the immune system during and after intense physical exercise. 200 mg Vitamin C taken daily in addition to the recommended daily dose (80 mg) contributes to the normal function of the immune system during and after intensive physical activity.

      (2) Energy levels: Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid and magnesium contribute to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. Magnesium contributes to electrolyte balance. Biotin, zinc and chromium contribute to normal macronutrient metabolism.

      (3) Digestion: Calcium contributes to the normal function of digestive enzymes. With vitamin A, biotin, riboflavin and niacin, AG1 contributes to the maintenance of normal mucous membranes (e.g. intestinal mucosa).

      (4) Focus; Mental performance; Psychological function; Nervous system: With pantothenic acid, AG1 contributes to normal mental performance. Zinc contributes to normal cognitive function. With vitamins C, B6, B12, B1, B3 and B7 AG1 contributes to normal psychological function and to normal functioning of the nervous system. Calcium contributes to normal neurotransmission.

      ‡ Additional health benefits:

      (5) Muscles: With calcium and magnesium, AG1 contributes to normal muscle function.

      (6) Cell Protection: With vitamins E and C as well as riboflavin, zinc, copper and selenium, AG1 contributes to the protection of cells from oxidative stress. Phosphorus contributes to normal function of cell membranes. Folate, Vitamin B6 and B12 contribute to normal homocysteine metabolism.

      (7) Skin, hair & nails: With vitamins A, as well as riboflavin, niacin, biotin and zinc, AG1 contributes to the maintenance of normal skin. Vitamin C contributes to normal collagen formation for the normal function of skin. Copper contributes to normal connective tissue. Vitamin B7, zinc and selenium contribute to the maintenance of normal hair. Zinc and selenium contribute to the maintenance of normal nails.

      (8) Hormonal system: With vitamin B6, AG1 contributes to the regulation of hormonal activity. Zinc contributes to the maintenance of normal testosterone levels in the blood. Selenium contributes to the normal thyroid function. With chromium, AG1 contributes to the maintenance of normal blood glucose levels.

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      © AG1
      The next generation of AG1 is clinically backed.

      RESEARCH STUDIES

      AG1 is backed by clinical research

      Our innovation is powered by continuous investment in scientific research and clinical discovery. We make sure the benefits of our product are thoroughly studied, and all claims are backed by a strong body of evidence – from ingredient-level research to clinical trials on the finished formula.
      The result? AG1 doesn’t just feel different – the impact is measurable.

      One product, four gold-standard clinical trials.

      AG1 has undergone multiple gold-standard clinical trials – repeatedly proving its effectiveness in supporting nutrient absorption across different populations and study designs.

      Tested for impact on:

      One product, four gold-standard clinical trials.

      AG1 has undergone multiple gold-standard clinical trials – repeatedly proving its effectiveness in supporting nutrient absorption across different populations and study designs.

      Tested for impact on:

      NUTRIENT LEVELS

      AG1 helps improve key nutrient levels within 3 months.ᵃ

      AG1 decreases Homocystein levels.ᵃ

      WHY THIS MATTERS

      Homocysteine ​​is an indicator of sufficient supply of B vitamins. A low-normal homocysteine level suggests a good B6, B12, and folate status – nutrients that among others support the homocystein metabolism. A functioning homocysteine ​​metabolism prevents the accumulation of intracellular homocysteine ​​and subsequent export into the blood, where it can contribute to oxidative stress.

      AG1 increases Vitamin C levelsᵃ

      WHY THIS MATTERS

      Representing antioxidants in AG1, vitamin C plays an important role in defending the body against oxidative stress³ and supporting immune function¹. As a powerful antioxidant, it’s essential to a wide range of physiological, psychological and cellular functions.¹ ² ⁴

      MICROBIOME

      AG1 is clinically shown to enrich the gut microbiome.ᵃ⁻ᶜ

      Over 10x average increase in friendly bacteria in the gut.ᵃ⁻ᶜ

      WHY THIS MATTERS

      These good bacteria live in the gut as part of a healthy microbiome.

      BIOAVILABILITY

      Key nutrients in AG1 were shown to be quickly and easily absorbed into the body.ᵈ

      Thiamine levels were significantly increased within 30 minutes of drinking AG1.ᵈ

      WHY THIS MATTERS

      AG1 delivers key nutrients like thiamine, biotin, riboflavin, niacin, vitamin C, zinc and folate – in bioavailable forms the body can easily and readily utilize, maximizing their potential benefits.

      a. In a triple-blind, randomised, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
      b. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts in 20 active adults ages 19-37.
      c. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts of 24 healthy adults with occasional GI distress ages 26-59.
      d. In a double-blind, randomised, placebo-controlled cross-over clinical trial assessing bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.
      The studies were conducted on a similar version of AG1's continually evolving formulation. The transferability of the study results is ensured because of comparable ingredients and amounts.

      What powers our research

      There are many ways to study how nutrition affects the body. In our clinical research, we use advanced tools and technologies – together with our academic and clinical partners – to explore the connection between nutrient intake and microbiome composition.

      Our Team

      Our research team

      Our in-house team of clinicians and scientists bring diverse expertise across nutrition, metabolism, microbiome, and related fields. We also collaborate with independent experts, academic institutions, and clinical partners to advance research and expand our understanding with cutting-edge technology.

      Dr. Ralph Esposito

      ND, Lac — Functional Medicine

      Dr. Esposito is a licensed naturopathic physician focused on optimising healthspan and lifespan through preventive and lifestyle practices. He completed his training as a medical intern in Urology at NYU Langone, holds a clinical Masters in Acupuncture and Chinese Medicine, and is a certified Functional Medicine doctor (IFMCP). Dr. Esposito employs evidence-based tactics to provide a personalized approach to preventative medicine. He is active in the health and education sectors, and is an Adjunct Professor in the Nutrition and Dietetics Program at New York University alongside his role as Chief Science & Nutrition Officer at AG1.

      Dr. Laura Kunces

      PhD, RD, CSSD — Exercise Physiology & Nutrition

      Dr. Kunces earned her PhD from the nationally top-ranked Kinesiology program at the University of Connecticut, was a tenure-track university professor, and since spent 12+ years in the health and wellness industry conducting and presenting research, managing scientific communications, and driving scientific business strategy. Her industry experience spans brands from small start-ups to large multinational companies, where she has consistently played a cross-functional role in management and R&D innovation. Dr. Kunces has two master's degrees in exercise physiology (University of Connecticut) and clinical nutrition (University of Memphis), is a registered dietitian, and is a board-certified specialist in sports dietetics.

      Dr. Jeremy Townsend

      PhD — Exercise Physiology

      Dr. Townsend earned his doctoral degree in Exercise Physiology from the University of Central Florida and has published over 80 peer-reviewed research articles focusing on sport nutrition, exercise performance, skeletal muscle physiology, and dietary supplementation. He has given numerous presentations and talks on nutrition and dietary supplementation at international conferences. Dr. Townsend is a Certified Sport Nutritionist (CISSN) through the International Society of Sport Nutrition (ISSN) and a Certified Strength and Conditioning Specialist with Distinction (CSCS*D) through the National Strength and Conditioning Association (NSCA). Dr. Townsend is currently the Research Manager at AG1 and an Adjunct Professor at Concordia University Chicago.

      Dr. Trevor Kirby

      PhD — Immunology and Microbiology

      Pharmaceutical Sciences and Molecular Medicine from Washington State University and a masters degree in Biology with an emphasis in Immunology and Microbiology from Eastern Washington University. His area of expertise centers on the connection between the human gut microbiome and the nervous system. He has published various research in the fields of immunology, microbiology, pharmacology, genetics, and biochemistry, and has given sponsored and educational talks on novel therapeutic microbiome approaches. Passionate about science and science education, Dr. Kirby regularly engages with the greater community through podcasts and volunteering with local high school student STEM groups. He is currently a Research Scientist at AG1.

      Dr. Philip Sapp

      PhD — Nutritional Science

      Dr. Sapp holds a doctoral degree in Nutritional Sciences from Penn State University and a masters degree in Exercise and Nutritional Sciences from Lipscomb University. He specializes in the effect of diet on cardiometabolic risk factors and the gut microbiome in adults at risk for chronic disease. As a clinical researcher, Dr. Sapp has designed, conducted, and presented on several clinical trials and has published numerous peer-reviewed papers and book chapters. Dr. Sapp is passionate about nutrition research and is currently a Research Scientist at AG1.

      Dr. Caitlyn Edwards

      PhD — Nutritional Science, Registered Dietician

      Dr. Edwards completed her doctoral degree in Nutritional Sciences at the University of Illinois at Urbana Champaign, and completed post-doctoral training at The Pennsylvania State University. She has experience in a variety of academic, industry, and non-profit settings, with over 50 published peer-reviewed articles in the fields of nutrition, neuroscience, technology, and eating behavior. Her research centers around the impact of dietary intake and eating behaviors on health across the lifespan. Alongside being a Nutrition Scientist, she is a Registered Dietitian with her certification of training in obesity in pediatrics and adults. Dr. Edwards is passionate about health and nutrition equity and helping others live happier and healthier lives. She is currently a Senior Research Scientist at AG1.

      Alexandra Wood, MSc

      MSc — Nutrition Science

      Alex received her Masters in Nutrition Science from The Friedman School of Nutrition Science and Policy at Tufts University. She previously worked on developing science-backed nutritional products for 5+ years, and is currently a Product Marketing & Education Manager on the Research, Nutrition and Innovation team at AG1. Alex is passionate about nutrition innovation, applying behavioral science principles to drive positive behavior change, and communicating evidence-based nutrition information to help others live their healthiest and happiest lives.

      Evan Lynch, MSc

      MSc — Sports Nutrition, Registered Dietician

      Evan Lynch is a CORU-registered dietitian with a BSc in Food Science and Health, a Postgraduate Diploma in Dietetics, and an MSc in Sports Nutrition. He is FODMAP trained and works across clinical, regulatory, and performance nutrition.

      Evan is the Head of Nutrition for Europe at AG1, where he supports strategic nutrition direction, education, and evidence-based communication. Alongside this role, he runs a private practice supporting clients across sports nutrition, gastrointestinal disorders, geriatric nutrition, and weight management, and provides nutritional support to scholarship athletes at University College Cork and residential care settings.

      He is a passionate science communicator focused on translating complex nutrition science into practical, accessible strategies for both athletes and clinical populations. His work and research interests include male health, disordered eating behaviours, and the role of neurodivergence in nutrition-related decision-making, with a focus on bridging clinical nutrition, sport science, and behavioural psychology to support sustainable, evidence-based outcomes.

      The clinical research lifecycle

      We’re proud to share that four clinical trials – rigorously designed, randomised, placebo-controlled trials – on the AG1 formula have been completed. This is a major milestone in our scientific journey and one that underscores our long-standing commitment to evidence-based innovation.

      Just like the trials themselves, the clinical research lifecycle is also rigorous, and it can be lengthy.

      The process of undertaking a trial, analysing the results, and publishing them can take years. But we know it’s worth the wait, because we’re committed to advancing science – not just for the sake of innovation, but to contribute meaningfully to advancing the science of nutrition and the microbiome forward.

      • AG1’s diverse team of clinicians, researchers, and PhDs work together to build initial studies.
      • The team conducted pre-clinical trials to inform the clinical trials. Pre-clinical studies were intentionally conducted to better understand the biological activity and mechanisms of AG1 – an approach that’s both common and foundational in the development of nutrition research. These early insights help inform the design of human clinical trials, enhancing scientific rigour and ensuring that future studies are strategically and effectively guided. Pre-clinical trials can take upwards of 8–10 months to design, implement and analyse the results.
      • We then partnered with independent contract research organisations (CROs) – the same groups trusted by other companies and academic institutions – to ensure data collection and analysis were objective and professionally managed.
      • To ensure scientific integrity and ethical compliance, each human study protocol was submitted for review and approval by an independent Institutional Review Board (IRB) prior to participant recruitment. IRB approval is a critical regulatory step that ensures the rights, safety, and well-being of study participants are protected, and that the research is conducted according to Good Clinical Practice (GCP) and applicable regulations. No human study began without formal IRB approval.
      • We then created detailed protocols with third-party scientists (also known as principal scientists) outlining specific criteria including the study population, endpoints, duration, measurements, and statistical plan. The research partners then recruited participants to ensure the most objective outcome for each study design. Participants and the third-party researchers in the trials were “blinded,” meaning they did not know they were taking AG1 or a placebo. As part of the design, our scientists and statisticians helped determine the power of the study – which refers to the likelihood that the study would detect a true effect if one existed, ensuring the results would be scientifically meaningful and not due to chance.
      • Each study was conducted over varying lengths of time, designed specifically to help answer the research questions – whether AG1 could measurably impact specific markers such as nutrient status, or microbiome composition in various populations from healthy individuals, active people to those with occasional gut issues.

      • The institution that conducted the study analysed and interpreted the results, and presented the findings to us. Given the volume and complexity of biomarker and microbiome data, we also partnered with advanced data science teams to ensure robust and accurate interpretation.
      • The data and research underwent strict scrutiny, not only from third-party scientists and statisticians, but also from our internal AG1 team including regulatory, research and legal teams.
      • Together, we identified the most meaningful and measurable insights – both about individual ingredients and the formula as a whole – that shaped the development and launch of AG1, and that continue to inform how we communicate the science behind our products.

      • We are committed to advancing scientific research through a level of integrity that goes well beyond the basic requirements for publication. The next phase of the publishing process starts with submitting abstracts – another word for summaries – to annual conferences.
      • Once accepted, these submissions may be chosen for poster (a visual summary of research findings) or an oral presentation. Abstracts are typically published post-symposium, and the timing can vary depending on the scientific meeting.
      • We’ve recently had abstracts accepted at several national scientific conferences, including:
        • 2025 American Physiology Summit (April 24–27), published here.
        • 2025 American Society of Nutrition (May 31–June 3)
        • 2025 American Society of Microbiology Annual Conference (June 19–23)
        • 2025 The International Society of Sports Nutrition Annual International Conference (June 23-25)
        • And more.
      • These abstracts are under embargo, meaning we can’t share them until they are presented at the conferences listed above. As they are published, we will update this page.
      • In parallel, AG1 is preparing full manuscripts containing more data from all four trials, which will be submitted to peer-reviewed journals over the coming months for publication.