RESEARCH STUDIES

The next generation of AG1 is clinically backed.

Our innovation is driven by our ongoing investments in research and clinical discovery. We ensure the benefits of our products are thoroughly researched and any claims are substantiated by multiple bodies of research on ingredients and the finished formula. The impact of AG1 Next Gen is not just experienced, it's measurable.*^1-4

One product, four gold-standard clinical trials.

AG1 Next Gen has been put to the test in multiple gold-standard clinical trials, consistently showing its efficacy in closing nutrient gaps and supporting gut health across diverse populations and study designs.*^1-4

One product, four gold-standard clinical trials.

Our research findings

NUTRITIONAL GAPS

AG1 Next Gen is clinically shown to fill common nutrient gaps even in healthy eaters.¹⁻⁴

WHY THIS MATTERS

In four randomized, placebo-controlled trials—meeting strict and widely accepted standards for clinical research—AG1 Next Gen demonstrated a statistically significant and positive impact on closing common nutrient gaps. These studies included participants with diverse diets, backgrounds, ages, and activity levels.¹⁻⁴

NUTRIENT LEVELS

AG1 Next Gen improves key nutrient levels within 3 months.¹

subjects drinking AG1 Next Gen had an increase in RBC folate.¹

WHY THIS MATTERS

Adequate micronutrients are needed to support the body in the production of energy, building proteins, and metabolizing food. They act as co-factors and individual building blocks. Maintaining consistent intake is key for overall health.*

increase in Vitamin C levels¹

WHY THIS MATTERS

Vitamin C supports the body's ability to combat oxidative stress and support immune defenses. It is a super antioxidant that plays a fundamental role in various physical and cellular processes.*

GUT HEALTH

AG1 Next Gen is clinically shown to enrich the gut microbiome.¹⁻³

Over

Average increase in healthy bacteria in the gut^1-3

WHY THIS MATTERS

Beneficial bacteria—such as the probiotic strains in AG1 Next Gen—are important for maintaining a healthy microbiome and play a key role in supporting overall gut health.*

BIOAVILABILITY

Key nutrients in AG1 Next Gen were shown to be quickly and easily absorbed into the body.⁴

Folate levels were significantly increased within 30 minutes of drinking AG1 Next Gen.⁴

WHY THIS MATTERS

AG1 Next Gen delivers key nutrients like folate, vitamin C, and zinc—in bioavailable forms the body can easily and readily utilize, maximizing their potential benefits.*

¹Triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
² Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37.
³ Double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 24 healthy adults with occasional GI distress ages 26-59.
⁴ Double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.

What powers our research

There are many ways to study how nutrition impacts the body. In our clinical research, we use advanced tools and technologies—alongside our academic and clinical partners—to explore the connection between nutrient intake and microbiome composition.

Our Team

Our research team

Our in-house team of clinicians and scientists bring diverse expertise across nutrition, metabolism, microbiome, and related fields. We also collaborate with independent experts, academic institutions, and clinical partners to advance research and expand our understanding with cutting-edge technology.

Peer-reviewed research

Beyond sharing our findings, we work with leading researchers to submit study manuscripts to peer-reviewed scientific journals—contributing to the broader scientific dialogue on the vital role of nutrition and the microbiome in overall health.

NUTRIENTS

Foundational Nutrition: Implications for Human Health

Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.

Read paper

FRONTIERS

Nutrient synergy: definition, evidence, and future directions

Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.

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NUTRACEUTICALS

The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®

Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

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APPLIED BIOSCIENCE

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms. Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms. Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

Read paper

FAQS

What studies have been done on AG1 Next Gen?

AG1 Next Gen has been studied across multiple clinical trials, consistently demonstrating its effectiveness in closing common nutrient gaps and supporting gut health.

Triple-blind, randomized, placebo-controlled trial (105 healthy adults who consumed a Standard American Diet) measuring nutrient biomarkers and microbiome changes.
Double-blind, placebo-controlled crossover trial (20 highly active healthy adults) assessing nutrient gaps and microbiome changes.
Double-blind, placebo-controlled crossover trial (24 healthy adults with occasional digestive discomfort) assessing nutrient gaps and microbiome changes.
Double-blind, placebo-controlled crossover trial (16 healthy adults) measuring nutrient absorption and bioavailability.

What did the studies find?

At a high-level, AG1 Next Gen was clinically shown to close common nutrient gaps—areas where the average diet may fall short—and support gut health, two critical factors for overall health, energy, and daily function. These results were consistent across multiple gold-standard clinical trials studying a range of lifestyles, including healthy adults who ate a Standard American Diet, highly active adults, and healthy adults experiencing occasional digest discomfort. You can learn more on our site.

What is a “gold standard” clinical trial?

Is this research published in peer-reviewed journals?

Several AG1 reviews and studies have already been published in leading peer-reviewed journals, including Nutrients, Frontiers, Nutraceuticals, and the Journal of Functional Foods. In addition to publishing the methodology and results on our site, the latest research on AG1 Next Gen has been submitted and is currently in the review process. The process is rigorous, and means the studies have been accepted after an in-depth evaluation by a panel of independent experts who ensure the data is accurate and unbiased.

What measures do you take to ensure the quality of AG1 Next Gen?

We’re proud to hold some of the highest standards in the supplement category. Since 2010, we have earned the trust of millions of people around the world with our relentless approach to quality, efficacy, and safety.

This includes rigorously testing AG1 for hundreds of contaminants, including heavy metals, allergens, and over 500 herbicides and pesticides. Through NSF Certified for Sport®, an independent third-party program that certifies dietary supplements are free from substances banned by major sporting organizations, we also test for over 280 banned substances, including stimulants, narcotics, diuretics, and masking agents.

You can read more about our standards and processes here.