RESEARCH STUDIES
Formulated for your body. Validated by research.

Since 2010, we’ve set out to formulate the most comprehensive and effective Foundational Nutrition supplement.

Our driving belief? High-quality ingredients combined with healthy gut function could improve the body’s ability to absorb and actually use essential nutrients.

RESEARCH TIMELINE

Setting a new standard in research

Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1. We followed a universally acknowledged hierarchy of scientific rigor, looking beyond ingredient data to test our complete formula and validate the synergy of how ingredients work together.

RESEARCH TIMELINE

Setting a new standard in research

Our in-house team of doctors, scientists, and researchers worked with third-party experts to conduct a set of scientific studies and further validate the benefits of AG1. We followed a universally acknowledged hierarchy of scientific rigor, looking beyond ingredient data to test our complete formula and validate the synergy of how ingredients work together.

01 — CLINICAL TRIAL RESULTS
Clinical Trial
A double-blind, randomized, placebo-controlled trial. We monitored 30 healthy adults ages 21-49 over 1 month, measuring the digestive impact of AG1 through stool samples. Research was conducted with a third-party expert to validate and mitigate bias.

AG1 was shown to enrich the gut microbiome, more than doubling the levels of healthy bacteria known to bolster digestion.¹*

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increase in healthy bacteria in the gut.¹

WHY THIS MATTERS
These healthy bacteria work together to break down food and are known to alleviate bloating, promote digestive regularity, and aid in digestive comfort long term.*

1 In a double-blind, randomized, placebo-controlled clinical trial assessing 30 healthy adults ages 21-49 over the course of 1 month.

02 — IN VITRO STUDY RESULTS
SHIME In Vitro Study
(Simulator of the Human Intestinal Microbial Ecosystem) A simulation of the human gastrointestinal tract, used to study the effects of AG1 on the gut in a controlled, highly reliable laboratory environment.

AG1 was shown to improve key markers of gut health, which helps power the body to make the most of the nutrients it consumes.¹*

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increase in short-chain fatty acid production.¹

WHY IT MATTERS
SCFAs are the superheroes of the gut. They provide energy to the cells in the digestive system and help keep the gut lining healthy. A strong gut lining plays a significant role in nutrient absorption and immune function.

1 In an in vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.

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increase in serotonin production in the gut.¹

WHY IT MATTERS
When serotonin is produced in the gut, it helps move nutrients through the digestive tract and alleviate occasional constipation.*

1 In an in vitro study conducted on 3 stool donors using a simulated model of the digestive tract in a controlled, laboratory design, AG1 was shown to improve indicators of gut health.

IN VITRO STUDY RESULTS CONT.
SHIME In Vitro Study
(Simulator of the Human Intestinal Microbial Ecosystem) A simulation of the human gastrointestinal tract, used to study the effects of AG1 on the gut in a controlled, highly reliable laboratory environment.

The powder form of AG1 was seen to digest faster than a multivitamin tablet, enabling better access to nutrients.¹*

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more minerals available for absorption vs. a multivitamin tablet.¹

WHY THIS MATTERS
Adequate nutrient levels are needed to deliver their intended benefits. The more accessible a nutrient is to the digestive tract, the easier it is for absorption.

1 In an in vitro study that compared AG1 powder to a multivitamin tablet using a simulated model of the digestive tract (SHIME).

03 — OBSERVATIONAL STUDY RESULTS
Observational Study
A single-arm study conducted with 35 healthy adults ages 25-48. We measured how participants reported feeling and behaving in different increments over the course of 3 months, and validated the data with a third-party clinical research organization to mitigate bias.

With regular use over 3 months, AG1 was seen to positively impact feelings of calm, energy, and improved digestion.¹

At 1 month¹

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of participants noticed less gas & bloating
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of participants noticed their bowel movements were more regular
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of participants felt more energy

At 3 months†

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of participants felt digestion improved
WHY IT MATTERS
Internal changes aren't always felt. By giving your body the routine nutrients it needs, you’re able to experience benefits that build each day.*

1 In a single-arm observational study conducted on 35 healthy adults ages 25-48 assessing the self-perceived efficacy of AG1 over 3 months.

“We intentionally designed AG1 to deliver a diverse spectrum of essential daily nutrients with pre and probiotics to support the gut, in a powder form that’s easier for your body to digest than a tablet.”*

Dr. Ralph Esposito ND, LAc — Functional Medicine, Chief Science & Nutrition Officer

Our Team & Findings

Our research team

To contribute to the emerging body of research on foundational nutrition and to keep AG1 at the forefront of it, we rely on an in-house team of doctors, scientists, and researchers dedicated to bringing you the highest quality supplement.

Peer-reviewed research

In addition to sharing our results, we collaborate with other experts and researchers in the scientific community to publish research in peer-reviewed scientific journals, helping to lead the discourse on the complex and crucial role nutrition plays in overall health.

NUTRACEUTICALS

The Novel Synbiotic, AG1®, Increases Short-Chained Fatty Acid Production in the Simulator of Human Intestinal Microbial Ecosystem (SHIME) Model®

Recently, there is growing usage of prebiotics and probiotics as dietary supplements due to their purported health benefits. AG1® (AG1) is a novel foundational nutrition supplement which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

Read paper
APPLIED BIOSCIENCE

AG1®, a Novel Synbiotic, Demonstrates Superior Mineral Bioaccessibility and Bioavailability Compared to a Tablet Multivitamin and Mineral Supplement Using an In Vitro Model of the Upper Gastrointestinal Tract

While traditional multivitamin and mineral (MVM) supplements generally come in tablet form, new powder forms of MVM supplements are available with theoretically higher bioavailability relative to tablet MVM supplements. which contains vitamins, minerals, phytonutrients, wholefood concentrates, adaptogens, and functional mushrooms.

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CURRENT ISSUES IN MOLECULAR BIOLOGY

AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal Microbial Ecosystem® Model

Considering previous experimental data on AG1 and the growing evidence that various phytochemicals can act as prebiotics, the primary objective of the current experiment was to detail the specific effects of AG1 on gut microbial community composition by observing changes in community structure and function.

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MICROORGANISMS

AG1®, a Novel Synbiotic, Maintains Gut Barrier Function following Inflammatory Challenge in a Caco-2/THP1-Blue™ Co-Culture Model

Nutritional interventions to reduce gastrointestinal (GI) permeability are of significant interest to physically active adults and those experiencing chronic health conditions. This in vitro study was designed to assess the impact of AG1, a novel synbiotic, on GI permeability following an inflammatory challenge.

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JOURNAL OF FUNCTIONAL FOODS

Changes in the fecal polar metabolome due to AG1 supplementation in the SHIME® model: A proof of principle study

Metabolomics is a critical approach to fully understand the metabolic repercussions of a nutritional supplement on the gut microbiota. Here, a proof of principle study was conducted via a metabolomic survey of polar metabolites to explore the effect of AG1 on the metabolic output of the human gut microbiota, in vitro, using the Simulator of the Human Intestinal Microbial Ecosystem® (SHIME).

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NUTRIENTS

Foundational Nutrition: Implications for Human Health

Human nutrition, and what can be considered “ideal” nutrition, is a complex, multi-faceted topic which many researchers and practitioners deliberate. While some attest that basic human nutrition is relatively understood, it is undeniable that a global nutritional problem persists.

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FRONTIERS

Nutrient synergy: definition, evidence, and future directions

Nutrient synergy refers to the concept that the combined effects of two or more nutrients working together have a greater physiological impact on the body than when each nutrient is consumed individually.

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One scoop. Every morning. For life.

One scoop. Every morning. For life.

FAQs

What is a SHIME model?

The SHIME model, which stands for Simulator of the Human Intestinal Microbial Ecosystem, is an in vitro model used in research to study the human gastrointestinal tract. It consists of a series of interconnected sections, called bioreactors, that mimic the physiological and biological conditions found in the human gut, including the stomach, small intestine, and colon.

Why did you start with an in vitro study?

What is a single-arm observational study?

How do you validate your research data on AG1?

What measures do you take to ensure the quality of AG1?