AG1 Next Gen’s Enhanced B Complex

Shedding light on the importance of B vitamins and their role in our newest formula

3 MIN READ — 05/16/2025

What Are B Vitamins?

B vitamins are essential to the body, as they help convert nutrients from food into energy.

Unlike other vitamins, which refer to one nutrient, vitamin B (or as we call them, B vitamins) actually refers to eight different vitamins, each with a distinct role. These include: thiamin (aka vitamin B1), riboflavin (aka vitamin B2), niacin (aka vitamin B3), pantothenic acid (aka vitamin B5), vitamin B6 (pyridoxine), biotin (vitamin B7), folate (vitamin B9), myo-inositol, and cobalamin (vitamin B12). (Interestingly, there is no vitamin B4, and myo-inositol was once considered vitamin B8.)

Although B vitamins are found in many foods like leafy greens, whole grains, eggs, and meat, certain factors, like stress, digestive issues, aging, and diet, can lead to deficiencies.

AG1 Next Gen’s Enhanced B Complex

Since 2010, AG1 has continuously upgraded its formula, guided by the latest research on nutrition. Our newest innovation, AG1 Next Gen, is a unique blend of enhanced ingredients that are clinically shown to close common nutrient gaps and support gut health—critical factors for daily function, energy, and foundational health. This includes an enhanced B complex, which works with other ingredients to support energy production. Because B vitamins are water-soluble, they’re not stored in the body in large amounts, meaning we need a steady supply.

  • We increased the amounts of B12: Methylcobalamin, aka methyl-B12, is an activated form of B12 that is quickly used by the body to promote healthy red blood cells, which are needed for energy. It’s especially helpful for those following a vegan or vegetarian diet.*
  • We increased the amount of B6: Vitamin B6 is an important nutrient for metabolizing protein, supporting healthy red blood cells and neurotransmitter production.*
  • We added myo-inositol: Once known as vitamin B8, myo-inositol complements other B complex vitamins to support cellular health.*
  • We added benfotiamine: Benfotiamine is a more bioavailable fat-soluble form of vitamin B1 and supports energy production.*

We added P5P: Pyridoxal-5-phosphate, aka P5P, is the bioactive form of vitamin B6, an important nutrient that supports brain function and the formation of red blood cells.*

B Vitamins and Homocysteine

In a clinical trial, AG1 lowered homocysteine levels by 10%.1 What does that mean and why does it matter? Homocysteine is an amino acid that is broken down by folate and B12. Optimal levels support cardio and cognitive health. If your B-vitamin intake is low, homocysteine can build up in the blood, potentially having a negative impact on health. B vitamins like B6 and B12 are key players in converting homocysteine into other beneficial substances, helping to keep levels in check.

Continuous Improvement, Always

As ever, AG1 is committed to continuous improvement and an emphasis on bioavailability to ensure that your Daily Health Drink is guided by the latest research and contains forms of vitamins, minerals, and whole food sourced ingredients that your body can actually absorb and use.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Information on the AG1 site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular health care provider.

** Offer valid for first time subscribers only.

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  1. In a triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
  2. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37.
  3. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 24 healthy adults with occasional GI distress ages 26-59 over the course of 4 weeks.
  4. In a double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.
  5. In a third-party, single-arm, closed label interventional study of 104 healthy adults ages 25-59 assessing self-perceived efficacy of AG1 Next Gen over 3 months.