AG1 Next Gen: The Formula

What’s changed from the original formula to this upgraded version?

3 MIN READ — 05/03/2025

To the naked eye or morning taste tester, there may be no discernible difference between AG1 Next Gen and the previous iteration of our formula. But, guided by years of research, four clinical trials on AG1 Next Gen, and significant product development, there are actually quite a few exciting ingredient upgrades to your Daily Health Drink. These include: added probiotics, more vitamins and minerals, and even more emphasis on bioavailability.

An Upgraded Probiotic Blend

Probiotics were a part of the existing formula, and we’ve closely followed the growing research on the effects they have on the gut microbiome. Based on this research, AG1 Next Gen includes five clinically studied probiotic strains shown to support digestive and immune health and help to alleviate bloating. Through an in vitro experimental design of the Simulator of Human Intestinal Microbial Ecosystem (SHIME®) model, we were able to see the efficacy of these five probiotics.

  • Lactobacillus rhamnosus GG
  • Lactobacillus acidophilus NCFM
  • Bifidobacterium lactis HN019
  • Lactobacillus casei LC-11
  • Lactobacillus plantarum LP-115

Additional Vitamins and Minerals

AG1 Next Gen also features an increase from 75 ingredients to 83, including these additional vitamins and minerals for more comprehensive nutrition support:

  • Boron: a trace mineral that works with calcium and magnesium to help their functions*
  • Choline: an often under-consumed nutrient that works to support the nervous system*
  • Cocoa extract: a concentrated form of cocoa that contains antioxidants called flavonols. New research shows that cocoa flavonols can act as a prebiotic and aid in the diversity of the gut microbiome.*
  • Molybdenum: a trace mineral that plays a role in cellular metabolism*
  • Myo-inositol: Once considered vitamin B8, myo-inositol complements other B complex vitamins to support cellular health.*
  • Rutin: a type of phytonutrient known as flavonoids which act as antioxidants and are known to play a role in overall immune health*

Bioavailable forms of existing ingredients:

We know that our bodies can better take in ingredients when they are in bioavailable (absorbable) forms. So, we’ve also incorporated, more active forms of existing ingredients into AG1 Next Gen like:

  • Active forms of B vitamins, like benfotiamine and pyridoxal-5-phosphate (P5P), to support energy production.*
  • A vitamin E complex instead of an isolated form (alpha tocopherols). This more closely reflects how the nutrient exists in nature, with enhanced bioavailability (absorption by the body) and a more broad spectrum source of the vitamin itself.*
  • Magnesium malate, (in addition to magnesium glycinate) for a more improved magnesium complex.*
  • Selenized yeast, which offers two bioavailable forms of selenium, selenomethionine and selenocysteine. Selenium is an essential trace mineral that’s critical to support the body’s antioxidant capacity.*

A Continued Approach to Safety, Quality, and Testing

One thing that hasn’t (and will never) change is AG1’s obsessive commitment to quality and testing. AG1 Next Gen is rigorously tested for hundreds of contaminants and impurities to guarantee that we’re delivering the highest quality nutrients to you each and every day. Additionally, we’ve gone a step further to raise the bar even more, by adapting our testing limits for heavy metals to meet both NSF and USP standards.

Continuous Improvement, Always

We believe that you should know the ‘why’ behind your daily AG1 Next Gen and hope that our upgraded formula can make you feel even more confident in your morning scoop.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular health care provider.

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  1. In a triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
  2. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37.
  3. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 24 healthy adults with occasional GI distress ages 26-59 over the course of 4 weeks.
  4. In a double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.
  5. In a third-party, single-arm, closed label interventional study of 104 healthy adults ages 25-59 assessing self-perceived efficacy of AG1 Next Gen over 3 months.

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