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  4. Do Multivitamins Really Work?

Do Multivitamins Really Work?

Do multivitamin supplements work, and how do you know whether you should take them? AG1’s experts explain what multivitamins are and the potential pros and cons of adding them to your diet.

10 MIN READ — 02/26/2025

Multivitamins are among the most popular nutritional supplements worldwide, often seen as an easy way to ‘cover your bases’ nutritionally. But do they really work, or are they simply marketing hype?

The answer is more nuanced than yes or no. While multivitamins can help fill nutrient gaps in certain situations, they’re not a shortcut to optimal health, and not all formulations are created equal. To understand their value, it helps to look at what the science says, who benefits most, and where a more complete approach may be needed.

Table of Contents

  • 01.

    What Are Vitamins, And Why Do They Matter?

  • 02.

    What Nutrients Should a Good Multivitamin Contain?

  • 03.

    The Vitamin D Question

  • 04.

    When Can Taking Multivitamins Be The Most Beneficial?

  • 05.

    The Limits and Risks of Multivitamins

  • 06.

    Multivitamins vs Single-Nutrient Supplements: Which Should You Choose?

  • 07.

    Remember: Food First, Supplements Second

  • 08.

    So, Are Multivitamins Worth It?

At a Glance

  • 01.

    Multivitamin complexes are a convenient way to take multiple essential vitamins and minerals vital for health and body functions, especially for active individuals.

  • 02.

    Since the body produces vitamin D when exposed to sunlight, it’s not always necessary to include it in multivitamin complexes, especially in the summer. However, during the winter months, this is the opposite, and the NHS actually advises people in the UK to take a vitamin D supplement to meet their body’s daily needs.

  • 03.

    Higher doses of certain vitamins can be beneficial in specific situations, like lowering cholesterol with vitamin B3. Multivitamin complexes, however, offer broader coverage and are often more affordable than single vitamins.

What Are Vitamins, And Why Do They Matter?

The short answer is: sometimes – it depends on who you are and what your body needs.

Large-scale studies show that multivitamins don’t act as a universal health shield. For generally healthy people who already eat a balanced diet, the evidence suggests little or no effect on outcomes like heart disease, cancer risk, or longevity. In other words, if you’re consistently getting a wide range of nutrients from food, a multivitamin may not have a significant impact.

That said, research published in medical journals also highlights clear benefits for specific groups:

  • Older adults, for example, often see improvements in memory and cognitive function when taking a daily multivitamin.
  • People with restricted diets (such as vegans, vegetarians, or those with food intolerances) can reduce their risk of deficiencies through supplementation.
  • Athletes or highly active individuals may find that multivitamins help support recovery and energy by topping up nutrients lost through training demands.

It’s also worth noting that not all multivitamins are the same. The type of nutrients used, their dosage, and how bioavailable they are (how easily your body can absorb them) make a significant difference. A product with poorly absorbed forms or token doses may do very little, while a thoughtfully formulated supplement can provide meaningful support.

This is one of the reasons why more comprehensive options – like AG1, a daily greens powder – exist: to go beyond the basics of a multivitamin and deliver a broader spectrum of high-quality, bioavailable nutrients designed to support whole-body health.

What Nutrients Should a Good Multivitamin Contain?

A well-formulated multivitamin should provide the vitamins and minerals most commonly under-consumed in the diet, but the quality and balance matter just as much as the list itself.

Core vitamins often included:

  • Vitamin A – supports vision, immunity, and skin health.
  • Vitamin C – important for immune function, iron absorption, and collagen production.
  • Vitamin D – crucial for calcium absorption, bone strength, and immune support.
  • Vitamin E – protects cells from oxidative stress.
  • Vitamin K – essential for blood clotting and bone metabolism.
  • B vitamins (including B12, folate, B6, niacin, riboflavin, thiamine) – vital for energy metabolism and nervous system function.

Key minerals often included:

  • Calcium – foundational for bone and teeth health.
  • Magnesium – supports muscle and nerve function, energy production, and recovery.
  • Zinc – contributes to immune resilience and wound healing.
  • Iron – necessary for red blood cell production and oxygen transport.

However, simply ticking boxes isn’t enough. Many lower-quality products rely on forms of nutrients that are harder for the body to absorb (for example, magnesium oxide or folic acid instead of methylfolate). Others underdose to the point where they may offer little real benefit. The most effective multivitamins focus not only on breadth of coverage, but also on bioavailability – how well your body can actually use the nutrients provided.

Did you know: AG1 has been clinically shown to increase vitamin C levels, which defend the body against oxidative stress and support normal immune function.

The Vitamin D Question

Vitamin D is one of the most important nutrients for long-term health, supporting bone strength, muscle function, and immune defences. Yet in the UK, it’s also one of the most common deficiencies.

Our bodies can produce vitamin D when skin is exposed to sunlight, but only between late March and the end of September, when the sun is strong enough. For much of the year, especially in northern parts of the country, UV levels are too low for meaningful production. Lifestyle factors (such as working indoors, limited time outside, darker skin tones, or regular sunscreen use) can also reduce how much vitamin D your body makes.

Because needs vary so widely, some multivitamin formulations choose to leave vitamin D out or include it in very small amounts, assuming people will supplement separately if necessary. This avoids the risk of oversupplementation but means many people are left with a deficit in autumn and winter.

Key takeaway: not every multivitamin provides enough vitamin D, so it’s important to check labels and consider seasonal needs, particularly in the UK. In fact, the NHS advises that everyone in the UK should consider taking a daily vitamin D supplement from October through March, and some at-risk groups are advised to supplement year-round. If you’re unsure, speak to a medical professional or nutritionist about your individual needs.

The Vitamin D Question

Vitamin D is one of the most important nutrients for long-term health, supporting bone strength, muscle function, and immune defences. Yet in the UK, it’s also one of the most common deficiencies.

Our bodies can produce vitamin D when skin is exposed to sunlight, but only between late March and the end of September, when the sun is strong enough. For much of the year, especially in northern parts of the country, UV levels are too low for meaningful production. Lifestyle factors (such as working indoors, limited time outside, darker skin tones, or regular sunscreen use) can also reduce how much vitamin D your body makes.

Because needs vary so widely, some multivitamin formulations choose to leave vitamin D out or include it in very small amounts, assuming people will supplement separately if necessary. This avoids the risk of oversupplementation but means many people are left with a deficit in autumn and winter.

Key takeaway: not every multivitamin provides enough vitamin D, so it’s important to check labels and consider seasonal needs, particularly in the UK. In fact, the NHS advises that everyone in the UK should consider taking a daily vitamin D supplement from October through March, and some at-risk groups are advised to supplement year-round. If you’re unsure, speak to a medical professional or nutritionist about your individual needs.

When Can Taking Multivitamins Be The Most Beneficial?

Multivitamins aren’t a one-size-fits-all solution, but they can play a meaningful role in situations where nutrient demands are higher, or where diet alone may not be enough.

1. Older adults

As we age, the body becomes less efficient at absorbing certain nutrients, particularly vitamin B12 and vitamin D. Appetite and dietary variety may also decrease, making supplementation an effective way to reduce deficiency risk and support healthy ageing.

2. People with restricted diets

Vegans and vegetarians may struggle to obtain nutrients like vitamin B12, iron, iodine, and zinc from food sources alone. Those with food intolerances or highly selective diets face similar challenges. A well-formulated multivitamin can help bridge these gaps.

3. Highly active individuals

Athletes, people who train intensively, or those with active jobs, can require higher amounts of micronutrients such as magnesium, zinc, and iron, and may also experience greater oxidative stress. A multivitamin can support recovery and energy levels by replenishing what the body uses more quickly.

4. Times of stress or illness

Periods of high workload, disrupted sleep, or recovery from illness can increase the body’s nutrient needs. Supplementation during these times can support the immune system and energy metabolism.

While multivitamins shouldn’t be relied on as a substitute for a balanced diet, they can be a helpful safety net in these scenarios. The key is ensuring the product is well-formulated, with nutrients in forms the body can absorb and in doses that meet, but don’t exceed, daily requirements.


The Limits and Risks of Multivitamins

While multivitamins can be helpful in certain situations, they aren’t a guarantee of better health. In fact, taking them without understanding your actual needs may provide little benefit, and in some cases, could potentially cause harm.

Here, Olivia Peleaz, the Product Education and Training Manager on the Research, Nutrition, and Innovation team at AG1, shares a few key points to consider when taking a multivitamin supplement.

1. Supplements aren’t a substitute for a balanced, healthy diet

Whole foods provide fibre, antioxidants, and phytonutrients that supplements can’t fully replicate. A nutrient-rich diet should always form the foundation of good health, with supplements to fill the gaps.

2. There is a risk of over-supplementation

More isn’t always better. Certain nutrients, especially fat-soluble vitamins like A, D, E, and K, can accumulate in the body if taken in very high doses. That’s why it's important to choose products with responsible formulations rather than megadoses.

3. The quality of multivitamins varies

The real difference lies in the formulation. Some multivitamins use nutrient forms that are harder for the body to absorb, or doses that don’t meaningfully support health. Others, like AG1, are designed with bioavailability in mind, offering nutrients in forms and amounts your body can actually use.

4. Remember the role of supplementation

While a multivitamin won’t replace healthy habits, it can play a valuable supporting role, especially during times of stress, restricted diets, or higher physical demands. Choosing high-quality supplements that provide more than just the basics is key.

The bottom line is that multivitamins and supplements work best when taken as part of a wider, holistic approach to well-being, supporting diet, lifestyle, and long-term health goals.

Multivitamins vs Single-Nutrient Supplements: Which Should You Choose?

When it comes to supplementation, there are two main approaches: broad coverage through a multivitamin or targeted support with individual nutrients. Which works best depends on your needs.

To help you decide the right option for you, here are some of the main features and benefits of each:

Multivitamins = broad nutrient coverage

  • Provide a wide range of vitamins and minerals in a single dose.
  • Useful as a general ‘safety net’ when dietary availability is limited, or when you want overall support without focusing on one or two specific nutrients.
  • Convenient and often more cost-effective than buying multiple single supplements.
  • Comprehensive blends like green powders like AG1 go beyond standard multivitamin tablets to include a mix of vitamins, minerals, and gut-friendly bacteria to support your gut’s microbiome. Together, these help support the normal function of your immune system, metabolism, and immunity, all in one simple addition to your daily routine.

Single-nutrient supplements = precision support

  • Designed to address a specific deficiency or higher requirement. For example, iron for anaemia, vitamin B12 for vegans, or vitamin D during winter months.
  • Allow more control over dosage and form (e.g., tablets vs capsules vs chewable pastilles).
  • Especially valuable when guided by blood tests or medical advice.

Finding the right fit for you

For many people, a high-quality multivitamin provides the necessary baseline coverage, while single-nutrient supplements can be added to a diet when targeted support is needed. In practice, the best approach for you may sometimes be a combination of both, as you can tailor supplementation to specific needs that differ depending on your current lifestyle, diet, health goals, and life stage.

Remember: Food First, Supplements Second

No supplement can replace the foundation of a healthy diet. Whole foods provide vitamins and minerals, fibre, antioxidants, and phytonutrients that work together in ways we’re only beginning to fully understand.

A diet rich in vegetables, fruits, wholegrains, lean proteins, and healthy fats remains the best way to support long-term health. These foods deliver nutrients in their natural context, where they’re often better absorbed and more effective than when isolated in supplement form.

That said, diet alone doesn’t always guarantee complete coverage. Busy lifestyles, dietary restrictions, seasonal changes, and higher activity levels can all create gaps that are hard to fill through food alone. This is where supplementation comes in — not as a replacement, but as a way to reinforce a strong nutritional base.

Think of it this way: food builds the foundation, while supplements provide an extra layer of support to help you meet your body’s needs more consistently and reliably, day after day.

So, Are Multivitamins Worth It?

For many people, the answer is yes, but with important caveats. Multivitamins can provide meaningful support when diet alone doesn’t cover every nutrient, especially for older adults, people with restricted diets, or those with higher physical demands. They’re also a convenient way to ensure consistent intake of essential vitamins and minerals in everyday life.

However, the effectiveness of any supplement depends on quality and formulation. A standard multivitamin may provide a baseline, yet it often misses the broader picture of what modern health requires – nutrients that support not just immunity and bone health but also energy, recovery, gut health, and resilience to stress.

That’s where greens powders like AG1 come in. By combining essential vitamins and minerals with probiotics, adaptogens, and phytonutrients in bioavailable forms, AG1 goes beyond the scope of a multivitamin. It’s a more comprehensive way to build consistency into your daily routine and give your body the diverse support it needs.

If you’d like to learn more about what makes AG1 unique, and how simple it is to make it a part of your daily routine, explore:

  • What is AG1?
  • AG1 Ingredients

Article Sources

Bakaloudi, D. R., Halloran, A., Rippin, H. L., Oikonomidou, A. C., Dardavesis, T. I., Williams, J., Wickramasinghe, K., Breda, J., & Chourdakis, M. (2021). Intake and adequacy of the vegan diet. A systematic review of the evidence. Clinical nutrition (Edinburgh, Scotland), 40(5), 3503–3521. https://doi.org/10.1016/j.clnu.2020.11.035

Vyas, C. M., Manson, J. E., Sesso, H. D., Cook, N. R., Rist, P. M., Weinberg, A., Moorthy, M. V., Baker, L. D., Espeland, M. A., Yeung, L. K., Brickman, A. M., & Okereke, O. I. (2024). Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS. The American journal of clinical nutrition, 119(3), 692–701. https://doi.org/10.1016/j.ajcnut.2023.12.011

https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/

​​https://www.nih.gov/news-events/news-releases/healthy-adults-taking-multivitamins-daily-not-associated-lower-risk-death

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Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the indicated daily intake. Keep out of reach of children. Please inform and consult your doctor before consuming this product. Not suitable for children and adolescents under 18 years, pregnant or breastfeeding women. Refrain from taking other food supplements containing zinc. Persons taking anticoagulant medication should seek medical advice before consuming vitamin K-containing supplements.

* Genuine reviews from customers who received a review link after purchase.

**Offer valid for new customers only upon signing up for a prepaid 3-month AG1 subscription. Regular price £199. Welcome Kit and gifts provided once. Subscription automatically renews unless cancelled beforehand.

↡ Ongoing survey of 3,000+ AG1 customers after 12+ days of use, 2024.

§ In a third-party, observational study conducted on 35 healthy adults ages 25-48 assessing the self-perceived efficacy of AG1 over the course of 3 months. The study was conducted on a similar version of AG1's continually evolving formulation. The study results are transferable because of comparable ingredients and amounts.

○ Ongoing survey of customers from 12 European countries who have been taking AG1 for an average of 9 days.

⬥ AG1 single subscriptions price and dose-matched average aggregated prices in 9 individual nutritional supplement categories with comparable ingredients. The prices of the individual supplements are the average prices of three individual products available online for each compared category, each with comparable ingredients. To ensure a fair basis for comparison, where the comparison products have different dosages, the prices were mathematically adjusted to correspond to the dosage contained in AG1. The 9 compared categories are vitamin B12, folate (Methylfolate), vitamin C, vitamin E, bacterial cultures, zinc, coenzyme Q10, greens powder and fibre.

Research Studies
a. In a triple-blind, randomised, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks.
b. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts in 20 active adults ages 19-37.
c. In a double-blind, randomised, placebo-controlled 2-week cross-over clinical trial assessing microbiome shifts of 24 healthy adults with occasional GI distress ages 26-59.
d. In a double-blind, randomised, placebo-controlled cross-over clinical trial assessing bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours.
The studies were conducted on a similar version of AG1's continually evolving formulation. The transferability of the study results is ensured because of comparable ingredients and amounts.

◊ Key health benefits:

(1) Immune system: With vitamins A, C, B6 and B12 as well as folate, zinc, copper and selenium, AG1 contributes to the normal function of the immune system. Vitamin C contributes to maintain the normal function of the immune system during and after intense physical exercise. 200 mg Vitamin C taken daily in addition to the recommended daily dose (80 mg) contributes to the normal function of the immune system during and after intensive physical activity.

(2) Energy levels: Vitamins C, B6, B12, riboflavin, niacin, pantothenic acid and magnesium contribute to normal energy-yielding metabolism and to the reduction of tiredness and fatigue. Magnesium contributes to electrolyte balance. Biotin, zinc and chromium contribute to normal macronutrient metabolism.

(3) Digestion: Calcium contributes to the normal function of digestive enzymes. With vitamin A, biotin, riboflavin and niacin, AG1 contributes to the maintenance of normal mucous membranes (e.g. intestinal mucosa).

(4) Focus; Mental performance; Psychological function; Nervous system: With pantothenic acid, AG1 contributes to normal mental performance. Zinc contributes to normal cognitive function. With vitamins C, B6, B12, B1, B3 and B7 AG1 contributes to normal psychological function and to normal functioning of the nervous system. Calcium contributes to normal neurotransmission.

‡ Additional health benefits:

(5) Muscles: With calcium and magnesium, AG1 contributes to normal muscle function.

(6) Cell Protection: With vitamins E and C as well as riboflavin, zinc, copper and selenium, AG1 contributes to the protection of cells from oxidative stress. Phosphorus contributes to normal function of cell membranes. Folate, Vitamin B6 and B12 contribute to normal homocysteine metabolism.

(7) Skin, hair & nails: With vitamins A, as well as riboflavin, niacin, biotin and zinc, AG1 contributes to the maintenance of normal skin. Vitamin C contributes to normal collagen formation for the normal function of skin. Copper contributes to normal connective tissue. Vitamin B7, zinc and selenium contribute to the maintenance of normal hair. Zinc and selenium contribute to the maintenance of normal nails.

(8) Hormonal system: With vitamin B6, AG1 contributes to the regulation of hormonal activity. Zinc contributes to the maintenance of normal testosterone levels in the blood. Selenium contributes to the normal thyroid function. With chromium, AG1 contributes to the maintenance of normal blood glucose levels.

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