Best Supplements for GLP-1 Users: Protein, Fiber, Electrolytes, and Daily Nutrient Support

GLP-1s can definitely support weight management and weight loss, but they can also change how much you eat, how hungry you feel, and how your digestion behaves day to day. Even when you are eating less, your body still needs steady nourishment. That means getting enough protein to support muscle, enough fiber to support digestion, enough fluids to stay hydrated, and enough vitamins and minerals to support everyday function.

Here’s how to think about GLP-1 supplement support in a simple, practical way.

Why nutrient gaps are common on a GLP-1

GLP-1s work partly by slowing gastric emptying and increasing feelings of fullness.¹ That can support weight management, but it can also mean that your meals are smaller, less frequent, or harder to finish.

A lower food intake means lower nutrient intake, too. One study of GLP-1 users found nutrient gaps across several key vitamins and minerals. Nearly all participants fell below recommended intake levels for vitamin D and potassium, and many also had nutrient gap for choline, magnesium, iron, calcium, vitamins A, C, D, E, and K.² Additional research and nutrition experts have also noted that reduced intake during GLP-1-assisted weight loss may affect nutrients such as protein, vitamin B12, thiamine, iron, calcium, and vitamin D.³

Of course, that does not mean every person on a GLP-1 needs the same supplements. But it does mean that eating less can make it harder to consistently meet your needs for protein, fiber, vitamins, and minerals. This is why it’s especially important to pay closer attention to nutrition when your appetite changes.

Protein: How much you need and why it supports your body on a GLP-1

Protein is an important nutrient to prioritize on a GLP-1. During weight loss, getting enough protein helps support lean mass, strength, and day-to-day energy.

A recent joint advisory on GLP-1 nutrition recommends individualized protein targets and notes that many adults may need higher protein intake during active weight loss, often around 1.2 to 1.5 grams per kilogram of body weight per day, depending on health status, activity level, and goals.⁴ (Your healthcare provider or Registered Dietitian can personalize that number for your unique needs.)

Protein can come from foods like:

• Greek yogurt or cottage cheese (about 15–25g protein per serving)
• Eggs (about 6g protein per egg)
• Fish, chicken, turkey, or beef (about 20–30g protein per 3-ounce cooked serving)
• Tofu, tempeh, beans, or lentils (about 8–20g protein per serving)
• Protein smoothies
• Protein powder added to oatmeal, yogurt, or shakes

If a full meal feels like too much to handle, a smaller protein-forward snack or smoothie may be easier for your appetite to tolerate.

Fiber: Keeping your digestion on track while on a GLP-1

GLP-1s can affect the speed of digestion, and some people notice changes in bowel patterns.¹ Fiber can help support digestive health, but it is best added gradually, especially if your appetite is lower or your digestion feels more sensitive.

Start with fiber-rich foods when you can: oats, berries, lentils, beans, chia seeds, vegetables, and whole grains. If you are not getting enough fiber through food, a fiber supplement for GLP-1 users may help fill the gap.

Increased fiber intake works best alongside other healthy habits, including staying hydrated, eating enough nutrient-dense food, and getting regular physical activity.

A few practical tips to keep in mind:

• Start with a smaller serving.
• Increase gradually.
• Pause and check with your healthcare provider if any digestive issues feel severe or persistent.

Electrolytes: Supporting hydration and energy on a GLP-1

When your appetite drops, it’s natural for your fluid intake to drop as well. Some people can also experience digestive discomfort, including occasional constipation, which can make hydration even harder to maintain.

Electrolytes are minerals that help support fluid balance, muscle function, and nerve signaling. Sodium, potassium, and magnesium are some of the main ones to look for. The best electrolytes for GLP-1 users are usually simple options that support hydration.

Electrolytes may be useful if you are:

• Drinking less than usual
• Sweating during workouts
• Eating smaller meals
• Dealing with digestive changes
• Feeling more depleted during the day

Water still comes first. Electrolytes can support hydration, especially when food and fluid intake are lower than normal. They can also help replace minerals lost through sweating or when eating and drinking less than usual, and may support fluid balance when appetite changes make it harder to meet your usual nutrition needs.

Still, more is not always better. Some people may be tempted to drink electrolyte beverages every day, even when they are already well hydrated. Because many electrolyte products contain sodium, regular use can add to total sodium intake, especially when combined with a typical diet. Most people should focus first on water and food-based hydration, using electrolyte support when they are losing more fluids through exercise, heat exposure, digestive changes, or reduced intake.⁵

When appetite changes affect how much you’re eating and drinking, paying attention to fluid and electrolyte intake supports overall wellness.

Daily nutrient support: Vitamins and minerals to watch on a GLP-1

Eating less makes it much harder to get enough of the nutrients that normally come from a varied diet, which is why paying attention to nutrient intake matters for GLP-1 users. This is why healthcare providers often encourage people taking GLP-1 medications to focus on nutrient-dense foods and pay attention to overall nutrient intake.

Nutrients that may require extra attention include vitamin D and calcium for bone health, as well as iron, B vitamins, magnesium, potassium, and fiber. The nutrients that deserve the most focus vary from person to person and depend on factors such as eating habits, food preferences, and overall health.

Should you take a daily multivitamin while on a GLP-1?

Daily nutrient support will certainly help fill nutrient gaps when your food intake is lower on a GLP-1. If you are considering a multivitamin or other supplement, it is a good idea to discuss it with your healthcare provider, especially if you take other medications or have specific nutrient needs.

AG1 Pro provides functional nutrients that support muscle health and metabolic function as part of a daily foundation.*

Start your day with AG1 Pro and support your body with daily nutrition designed for changing routines.*

How to build a simple supplement routine on a GLP-1

A supplement routine on a GLP-1 should work with your appetite, not against it. If large meals feel difficult, it can help to spread nutrition across smaller moments in the day instead of trying to make one meal do all the work.

• Start with the part of your routine that feels most consistent. For some people, that’s breakfast. For others, it’s a mid-morning smoothie or something small after a workout. Use that anchor point to build in the basics.
• In the morning, you might mix AG1 Pro with water to help support daily nutrient intake, then add a protein-rich food or smoothie if solid food feels manageable. Later in the day, focus on getting more protein, even in a small portion. Greek yogurt, eggs, cottage cheese, chicken, tofu, or a protein shake can all help make that easier.
• Fiber is also important, but go slowly. If your digestion already feels sensitive, adding a large fiber supplement right away may be uncomfortable. Start with fiber-rich foods when you can, then consider a smaller serving of supplemental fiber if your intake is still low.
• Electrolytes do not need to be a daily thing. They are best when your hydration is harder to maintain, such as on days when you are drinking less, sweating more, or dealing with some of the digestive changes that can occur with GLP-1 use.

How AG1 Pro can help

A simple GLP-1 supplement routine might look different from day to day, and that is fine. The goal is to create a few reliable habits that help you meet your protein, fiber, fluid, and daily nutrient needs without adding more effort than you can realistically keep up with.

AG1 Pro is built on AG1 Next Gen, with added support for muscle preservation, metabolic resilience, and advanced gut barrier health.* With 80+ ingredients, including vitamins, minerals, prebiotics, probiotics, phytonutrients, creatine monohydrate, Ca-HMB, and zinc carnosine, it’s designed to help complement reduced intake and help fill nutrient gaps that may occur while using GLP-1s.*

AG1 Pro can be one simple way to support daily nutrient intake as part of your GLP-1 routine, with vitamins, minerals, prebiotics, probiotics, phytonutrients, creatine, and whole-food-sourced ingredients in one scoop.*
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References:

1. Collins L, Costello RA. Glucagon-Like Peptide-1 Receptor Agonists. In: StatPearls. StatPearls Publishing; updated February 29, 2024.
2. Johnson B, Milstead M, Thomas O, et al. Investigating nutrient intake during use of glucagon-like peptide-1 receptor agonist: a cross-sectional study. Front Nutr. 2025;12:1566498. doi:10.3389/fnut.2025.1566498
3. Spreckley M, Ruggiero CF, Brown A. Bridging the nutrition guidance gap for GLP-1 receptor agonist therapy-assisted weight loss: lessons from bariatric surgery. Int J Obes. 2026;50:265-267. doi:10.1038/s41366-025-01952-w
4. Mozaffarian D, Agarwal M, Aggarwal M, et al. Nutritional priorities to support GLP-1 therapy for obesity: a joint advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Obesity. 2025;33:1475-1503. doi:10.1002/oby.24336
5. Centers for Disease Control and Prevention. About sodium and health. Updated March 31, 2026. Accessed June 9, 2026.