1. Home
  2. Health Guides
  3. Benefits of Omega-3 with CoQ10
Fish containing coq10 and omega-3 sit in a small orange container packed with ice and salt with a lemon wheel

Benefits of Omega-3 with CoQ10

Reviewed by: Philip Sapp, PhD, Senior Research Scientist, Research
4 MIN READ — 5 Citations — 07/16/2026

The benefits of Omega-3 with CoQ10 range from cardiovascular support to cellular energy. Research indicates that omega-3 fatty acids and CoQ10 each support whole-body health through complementary mechanisms.*

Key takeaways

  • 01.

    CoQ10 is fat-soluble, which means your body absorbs it better when you take it with a fat. Omega-3-rich fish oil provides that fat, making these two nutrients a practical and effective pair.

  • 02.

    Both omega-3 fatty acids and CoQ10 support mitochondrial function and cellular energy production. This helps your cells produce energy to power you through the day.

  • 03.

    DHA omega-3 is a structural component of your brain that supports cognitive function*

  • 04.

    Your body's natural production of CoQ10 decreases with age, making dietary intake or supplementation more relevant over time.

What are omega-3 fatty acids and CoQ10?

Omega-3s:
While there are several types of omega-3 fatty acids, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) have been shown to provide the most benefit and are most reliably obtained from marine sources, including fatty fish and algae.1 EPA and DHA are critical components of the cell membranes throughout your body, including the membranes of brain cells (neurons), retina cells, and cardiac cells.1 EPA has been shown to support cardiovascular health, and research suggests that DHA helps maintain cognitive function, vision health, and overall brain health throughout your life.1,2 Now that's a lot of benefits!

CoQ10:
CoQ10 is a fat-soluble antioxidant and enzyme cofactor that your body uses to support energy production in your mitochondria (the parts of your cells that create energy your body can use). Your body's natural production of CoQ10 declines over time, so many adults consider supplements to cover this gap.3

Foods high in omega-3 fatty acids include:

Fish

EPA+DHA per 3.5oz (100g)

Sardines

982mg

Mackerel

1,200mg

Salmon

2,150mg

Herring

~2,100mg

Rainbow trout

~875mg

Why take omega-3 and CoQ10 together?

On the biology side of things, these nutrients overlap by supporting similar functions—namely heart health and energy production at the cellular level—but they do so in different ways. Taken together, they work more effectively.

  • While omega-3s can help support the flexibility of blood vessels, CoQ10 helps provide energy to the heart and other tissues that require significant amounts of energy to do their jobs.1,3
  • As for absorption, CoQ10 is fat-soluble and is better absorbed in the presence of dietary fat.
  • By consuming CoQ10 with a fish oil supplement instead of alone, you may be able to support greater bioavailability of CoQ10 in the body.3
  • Both omega-3 fatty acids and CoQ10 are well-tolerated nutrients that are commonly taken together as part of a daily supplement routine.

Benefits of omega-3 fatty acids and CoQ10

Heart health and cardiovascular benefits

Omega-3 fatty acids EPA and DHA help support the health of your heart and promote normal blood vessel function.1 EPA has been shown to play a significant role in heart health, while DHA acts as a structural element of heart tissue.1

Since CoQ10 is highly concentrated in tissues with high energy requirements (like the heart), it helps support energy production in cells' mitochondria.3 By helping to provide this metabolic energy, CoQ10 supports the function of heart tissue.3

Both nutrients have research behind them that supports heart health and normal blood vessel function, making them a good combination for adults who want to support cardiovascular wellness.1,3

Cellular energy and mitochondrial benefits

One primary role of CoQ10 is to create ATP (adenosine triphosphate), which is the primary molecule that provides energy to cells throughout the body.3 Helping to maintain healthy levels of CoQ10 allows your cells to keep producing energy—especially in tissues that require more energy to function properly, such as the heart, brain, and muscles.3

Omega-3s help maintain healthy cell membranes, enabling proper cellular signaling and supporting healthy mitochondria.1 In short, these two nutrients support cellular energy production and utilization from complementary directions.

Antioxidant effects of omega-3 fatty acids and CoQ10

CoQ10 is one of the body's major fat-soluble antioxidant defenses.3 It supports the body's natural antioxidant defenses at the cellular level.3

DHA and EPA, as key components of cell membranes, help maintain the structural environment that supports normal cellular function and resilience.1

How to add omega-3 with CoQ10 to your daily routine

Since CoQ10 is fat-soluble, taking it with food that contains dietary fat or a fish oil supplement will enhance absorption. That's one of the practical advantages of taking CoQ10 with omega-3 in a single supplement—the fish oil serves as the fat-delivery system for CoQ10.

AG1 supplement solutions

AG Omega3 + CoQ10 features EPA and DHA omega-3 fatty acids and CoQ10 in one easy-to-swallow daily capsule. It supports heart health, cellular energy production, and healthy aging, all in one.* Plus, it's NSF Certified for Sport® (third-party tested) and certified by International Fish Oil Standards (IFOS™), one of the most comprehensive third-party fish oil testing programs around. The omega-3s are sourced from Friend of the Sea-certified sustainable fisheries and are provided in triglyceride form for optimal absorption.

AG Omega3 + CoQ10 is designed to complement AG1 Next Gen as part of a daily nutrition system, with the formula kept separate from AG1 to support optimal absorption of these essential fatty acids. If you're ready to support your cardiovascular health and cellular energy with a clinically studied omega-3 and CoQ10 pairing, explore AG Omega3 + CoQ10.

References:

  1. Harris WS, Mozaffarian D, Rimm E, et al. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association. Am J Clin Nutr. 2009;89(5):1588S-1592S. doi:10.3945/ajcn.2008.26811E
  2. Araújo JP, Ceia F, Gonçalves I, et al. Omega-3 fatty acids and cognitive decline: a systematic review. Nutrients. 2017;9(8):807. doi:10.3390/nu9080807
  3. Barainua S, Robles NR, Ferreras A, et al. Coenzyme Q10 supplementation in cardiovascular disease: a systematic review and meta-analysis. Front Pharmacol. 2021;12:624091. doi:10.3389/fphar.2021.624091
  4. Sanoobar M, Dehghan P, Khalili M, Azimi A, Seifar F. Coenzyme Q10 as a treatment for neurological brain conditions: a double-blind randomized controlled trial. Nutritional Neuroscience. 2016;19(3):138-143. doi:10.1179/1476830514Y.0000000164
  5. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central. https://fdc.nal.usda.gov

Connect

Join Our Newsletter

© 2026 AG1

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular health care provider.

** AG1 Welcome Kit Offer valid for new AG1 subscribers only. AG1 Pro Welcome Kit included with the first AG1 Pro subscription order only. AGZ Frother Offer valid for first AGZ order only.

◊According to IQVIA Pro Voice Survey of 248 primary care physicians in December 2025.

††Free shipping on subscription purchases for new U.S. customers only.

  1. In a triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks using the AG1 Next Gen formula.
  2. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37 using the AG1 Next Gen formula.
  3. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 40 healthy adults with occasional GI distress ages 26-59 over the course of 4 weeks using the AG1 Next Gen formula.
  4. In a double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours using the AG1 Next Gen formula.
  5. In a third-party, single-arm, closed label interventional study of 104 healthy adults ages 25-59 assessing self-perceived efficacy of AG1 Next Gen over 3 months.

ΔTruemed eligibility and approval required. This link will take you to a third party website hosted by Truemed (the "Site"). Linking to this Site does not constitute an endorsement or approval by AG1 or any of its employees of the content, products, services or opinions on the Site. This is being provided as a convenience and AG1 bears no responsibility for the accuracy, legality or content of the Site or for that of any subsequent links on the Site. Contact the owners of the Site for answers to questions regarding its content.

Actual Packaging May Vary

Your privacy is our priority. Learn more: