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  • AG1 ProNEW

    Advanced daily nutrition with creatine and more.

  • AG1 Next GenBest Seller

    Our flagship, clinically-backed formula.

  • AG1 Essentials Gummies

    Daily nutrition + 5g fiber in a tasty gummy.

  • Shop All

    Discover our member favorites here.

Shop AGZ

  • AGZ for Sleep

    Melatonin-free sleep support.

Additional Support

  • AG Omega3ENHANCED

    Support brain, heart, and immune health.

  • AG Omega3 + CoQ10NEW

    Support heart health, cellular energy, and healthy aging.

  • Vitamin D3 + K2

    Complement AG1 with additional support for immune and bone health.

  1. Home
  2. Ingredients
  3. Milk Thistle Seed Extract Facts

Milk Thistle Seed Extract Facts

Milk thistle (Silybum marianum) is a flowering herb native to the Mediterranean region. Its seeds contain silymarin, a complex of flavonolignans studied for their ability to support liver health, antioxidant defenses, and nutrient metabolism.

Key Benefits of Milk Thistle Seed Extract:

  • Helps support normal liver function, bile flow, and antioxidant defenses.
  • Provides antioxidant silymarin compounds.
  • May support healthy nutrient metabolism and bile production.

Why it Matters:

Liver health is central to overall wellness: The liver helps manage nutrient metabolism, elimination pathways, and bile production, all of which are vital for daily function.

Products Included

AG1 Pro (30ct)New

AG1 Pro (30ct)

Everything in AG1 Next Gen plus creatine and more for advanced muscle and gut support.*

From $99/mo$119†
Original1 flavor
AG1: PouchBEST SELLER

AG1: Pouch

Nutrients and gut health support in one Daily Health Drink.*

From $79/mo$99†
Original3 flavors
AG1 Energy+ (14ct)LIMITED TIME

AG1 Energy+ (14ct)

The AG1 Next Gen foundation with 100mg plant-based caffeine and 100mg L-theanine added for extra energy and focus.*

$49
Mango Sunrise1 flavor
† Value of one-time purchase

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Information on this site is provided for informational purposes only. It is not meant to substitute for medical advice from your physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. Carefully read all product documentation. If you have or suspect that you have a medical problem, promptly contact your regular health care provider.

**Valid 11/1/26 to 11/15/26. New subscribers only. $29 applies to the first shipment of a new monthly AG1 Essentials Gummies subscription; renews at $49 per month until canceled. Savings of $35 (55%) are based on the $29 promotional first order price compared to the $64 one time purchase price. Cannot be combined with other offers or applied to prior purchases.

**Limited time offer for new AG1 Next Gen and AG1 Pro subscriptions only. Cannot be combined with other offers, discounts, or applied to prior purchases. AG1 subscription required. While supplies last.

** AG1 Welcome Kit Offer valid for new AG1 subscribers only. AG1 Pro Welcome Kit included with the first AG1 Pro subscription order only. AGZ Frother Offer valid for first AGZ order only.

◊According to IQVIA Pro Voice Survey of 248 primary care physicians in December 2025.

‡Free shipping on subscription purchases for new U.S. customers only.

  1. In a triple-blind, randomized, placebo-controlled parallel-designed clinical trial evaluating nutrient biomarkers and microbiome shifts in 105 healthy adults ages 20-59 over the course of 12 weeks using the AG1 Next Gen formula.
  2. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome shifts in 20 active adults ages 19-37 using the AG1 Next Gen formula.
  3. In a double-blind, randomized, placebo-controlled 2-week crossover clinical trial assessing nutrient gaps and microbiome assessments of 40 healthy adults with occasional GI distress ages 26-59 over the course of 4 weeks using the AG1 Next Gen formula.
  4. In a double-blind, randomized, placebo-controlled crossover clinical trial assessing nutrient gaps and bioavailability in 16 healthy adults ages 18-42 over the course of 8 hours using the AG1 Next Gen formula.
  5. In a third-party, single-arm, closed label interventional study of 104 healthy adults ages 25-59 assessing self-perceived efficacy of AG1 Next Gen over 3 months.
  6. In a third-party, open-label, randomized controlled clinical study of self-reported sleep and daytime sleepiness measures in 149 adults ages 26-59 taking AGZ over 30 days.

ΔTruemed eligibility and approval required. This link will take you to a third party website hosted by Truemed (the "Site"). Linking to this Site does not constitute an endorsement or approval by AG1 or any of its employees of the content, products, services or opinions on the Site. This is being provided as a convenience and AG1 bears no responsibility for the accuracy, legality or content of the Site or for that of any subsequent links on the Site. Contact the owners of the Site for answers to questions regarding its content.

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